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This has been described before in only one patient with therapeutic doses of doxycycline, 1 and in a patient with self-induced doxycycline intoxication (1 g/day during 12 years leading to doxycycline serum concentrations of 34 mg/ml, normal therapeutic range: 1-5 mg/ml, for chronic Q-fever: 5-10 mg/ml)

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PMID: 15976791, PMCID: PMC2790272, DOI: 10.1016/j.ahj.2004.08.018

Observational studies of the association between glucose-lowering medications and cardiovascular outcomes: addressing methodological limitations