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Their risk profiles vary depending on their cellular targets

The anti-inflammatory properties of NSAIDs are due to their inhibition of the cyclooxygenase (COX) enzymes , which catalyze the synthesis of localized pro-inflammatory signaling molecules called prostaglandins (Toussaint 2010)

The meta-analytical study shows decreased abundance in the MDD patients when compared to controls in the bacterial families Veillonellaceae, Prevotellaceae, and Sutterellaceae, genera Coprococcus, Faecalibacterium, Ruminococcus, Bifidobacterium, Escherichia , and shows an increase in abundance in Actinomycetaceae family and Paraprevotella genus (Sanada et al., 2020)

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