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Eysiaks et al

Therapeutic algorithms to treat neuropathic pain include molecules acting on 2 subunits of calcium channels, sodium channels, and descending modulatory inhibitory pathways [13]

Illustrative alkyl groups are, but not limited to, methylene, ethylene, n-propylene, isopropylene, n-butylene, isobutylene, sec-butylene, pentylene, 1,2-pentylene, 1,3-pentylene, hexylene, heptylene, octylene, and the like

heteroatom linkers can also be included in the polyvalent linker L, such as -NR R 2 -, oxygen, sulfur, and the heteroatom linkers may be used to covalently attach any of the radicals described herein, including drug radicals D to the polyvalent linker, ligand radicals B to the polyvalent linker, or various di and polyvalent radicals that from the polyvalent linker L the polyvalent linker L is a releasable linker