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Compounded versions may require different doses Semaglutide was approved by the US Food and Drug Administration in 2017

Teixeira LG, Leonel AJ, Aguilar EC, Batista NV, Alves AC, Coimbra CC, et al

Animal Model:Neonatal Sprague-Dawley rats (male, 18-22g, postnatal day 7), hypoxic-ischemic brain damage (HIBD) model [2] Dosage:100 mg/kg Administration:Intraperitoneal injection, once daily, for 14 consecutive days starting 24 hours after HIBD induction Result:Brain injury: Reduced infarct volume by 40% compared to the HIBD control group as measured by triphenyltetrazolium chloride (TTC) staining

Regarding the inflammatory response, it has been shown that intracellular GSH depletion represents the first event in the signaling process