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This approach mainly accounted for the possibility that a proportion of patients could have switched from DPP4 inhibitors to GLP1 receptor agonists during follow-up (a potential thyroid cancer risk with GLP1 receptor agonists could spill over into the group classified as receiving DPP4 inhibitors according to the intention-to-treat definition for drug use, which might lead to an underestimation of thyroid cancer risk with GLP1 receptor agonists)
(Given the potential long-term consequences of NMOSD relapses, the company could not ethically include a direct placebo arm in its Phase III trial.) Ultomiris was well-tolerated overall, and most treatment-emergent events were mild or moderate in severity, according to AstraZeneca
This selectivity means tanning effects are achieved with limited activation of MC3R, MC4R, and MC5R the receptors responsible for off-target effects such as libido modulation (MC4R), appetite suppression (MC4R/MC3R), and sebaceous gland activity (MC5R)
