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The choice between liraglutide and semaglutide for weight loss often depends on factors such as the patients medical history, their tolerance to the medication, and their preference for daily versus weekly administration
These drugs also appear to have major pleiotropic effects in CV risk reduction, (STEP trials , SELECT trial, STEP HFpEF, SCRIBE, SUMMIT, SURMOUNT-MMO (completion 2027)) reversal of metabolic dysfunctionassociated steatotic liver disease (MASLD), previously known as non-alcoholic fatty liver disease (SYNERGY NASH MASH), and non-progression if not reversal of chronic kidney disease (CKD) (FLOW trial)
Most semaglutide side effects are mild and resolve with time