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Some conditions that can cause this vitamin B12 deficiency include: Atrophic gastritis, an inflammation of the stomach Surgical removal of part of the stomach or intestines Conditions that affect your intestine's ability to absorb nutrients, such as Celiac disease Pancreatic insufficiency Alcoholism Acquired immune deficiency syndrome (AIDS) Some people who don't have enough of a protein called the "intrinsic factor" also have a vitamin B12 deficiency