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Ongoing research is ongoing to explore broader therapeutic applications

Regarding pharmacotherapy, Dutch standards recommend a stepwise introduction of treatments based on glycated haemoglobin (HbA1c), starting with metformin then sequentially adding sulphonylureas, followed by the addition of insulin or glucagon-like peptide-1 receptor agonists (GLP-1RAs) or dipeptidyl peptidase-4 (DPP-4) inhibitors as required to achieve and maintain glycaemic targets [9]

In future, the treatment strategy of HT will be around the gut-thyroid axis gradually, aiming to slow down the progress of HT and improve the symptoms of patients by rebuilding the intestinal microbial ecology

However, they do come with some side effects, which we will discuss in the next section