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Materials and methods Animal experiment Female homozygous leptin receptor-deficient (db/db) mice on a C57BL/6 background ( n = 40) and wild-type (WT) C57BL/6 mice ( n = 20), purchased from the Animal Laboratory Center of Nanjing University (China), were used in this study

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Clinicians should ask about positive and negative emotional triggers for off-plan, loss of control, or late-night eating, such as sadness, anger, boredom, or social events

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