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In 2022, drugmakers inability to keep up with demand for GLP-1s opened the floodgates to compounded versions

Most subjects were non-smokers (86%)

As shown in Figure 3A, reduced expression levels of IL-6 and 8 and MMP3, 12 and 13 were observed in the FOXO4-DRI treated group, which however were concomitantly accompanied with reduced expression of SOX9 and COL2 , as well as increased expression of CDKN2A, CDKN1A , and TP53 (encoding p53)

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