Tirzepatide activates two hormone pathways (GLP-1 and GIP), whereas semaglutide targets only GLP-1, making tirzepatide generally more potent for appetite suppression and fat loss
Primary action: Innate repair receptor activation Best for: Neuropathic pain, small fiber neuropathy, chronic inflammation, nerve regeneration Pairs well with: Wolverine (BPC-157 + TB-500), Core Spark (SS-31), Calm Within (KPV) Primary action: Tissue repair, tendon and ligament healing, gut restoration Best for: Musculoskeletal injuries, post-surgical recovery, gut health Pairs well with: ReWire (ARA-290), KLOW, Build & Define (IGF-1 LR3) Primary action: Mitochondrial membrane stabilization Best for: Cellular energy, exercise recovery, aging-related fatigue Pairs well with: ReWire (ARA-290), Better Vitality NAD+, Cellular Longevity (Epithalon) Primary action: Anti-inflammatory tripeptide (alpha-MSH derivative) Best for: Gut inflammation, skin inflammation (eczema, psoriasis), immune modulation Pairs well with: ReWire (ARA-290), KLOW, VIP The most common stacking pattern we see in Lincoln Park is ReWire + Wolverine for patients with both nerve damage and soft tissue injury, or ReWire + Core Spark for patients who want nerve repair plus mitochondrial optimization
Ozempic is FDA-approved to manage Type 2 Diabetes
To help with emotional and behavioral symptoms, your doctor may also prescribe antidepressants and antipsychotics
