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For example, METH and cocaine disrupt monoaminergic signaling, whereas ketamine and nitrous oxide impair glutamatergic neurotransmission

The brain does not exist in isolation from the kidneys, the heart, or the metabolism

Taken together, since the excess activation of ACSL4, LPCAT3 and ALOXs are considered key drivers of ferroptosis, decreasing their expression will reduce the accumulation of lipid peroxides, thus inhibiting ferroptosis progression