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The role that metabolism plays in the inactivation of lipid-soluble drugs can be quite dramatic

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Vill K, Muller-Felber W, Landfarth T, Koppl C, Herzig N, Knerr C, Holla H, Steidle G, Harms E, Hohenfellner K, Interdisciplinary Cystinosis Group (2022) Neuromuscular conditions and the impact of cystine-depleting therapy in infantile nephropathic cystinosis: a cross-sectional analysis of 55 patients

Growth Hormone & IGF Research (1999) This study demonstrated Ipamorelin's effects on longitudinal bone growth in rat models