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Rather, the GSH pool remains rather constant while even marked increases in total glutathione are almost entirely due to the accumulation of GSSG (Smith et al., 1985

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Seven modified cysteine sites were confirmed, including Cys112 in GSTA1, Cys78 in GSTM1, Cys115 and 174 in GSTM2, as well as Cys15, 48, and 170 in GSTP1

Research has shown GHK-Cu influences expression of over 4,000 human genes, stimulates collagen I, III and elastin synthesis, activates matrix metalloproteinases for extracellular matrix remodelling, supports angiogenesis through VEGF and FGF upregulation, and suppresses pro-inflammatory TNF- signalling