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Mizobuchi M, Hatamura I, Ogata H et al

Dupilumab efficacy and safety in adults with uncontrolled persistent asthma despite use of medium-to-high-dose inhaled corticosteroids plus a long-acting 2 agonist: A randomised double-blind placebo-controlled pivotal phase 2b dose-ranging trial

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Berberine may also slow gastric motility in some individuals, and since GLP-1 medications already delay stomach emptying, this combination could theoretically increase digestive side effects such as nausea, constipation, or bloating