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Although this field is still evolving, understanding how GLP-1 therapies interact with the gut microbiome may help explain their broad metabolic benefits

Retatrutide In early-phase trials, Retatrutide showed substantial weight loss (up to 24.2% over 48 weeks)

Psychiatry 33 , 7075 (2009)

A steady reduction in astrocytic glutamate transporters, reduced capacity to buffer and disperse K + , and an overall decrease in their ability to sense synaptic activity (partly due to reduced density of ionotropic receptors) was also observed in aged mice (2024-months-old), disrupting long-term potentiation of synapses in the hippocampus (Lalo et al., 2011