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Never pack semaglutide in checked luggage where cargo hold temperatures can drop below freezing, and avoid placing it directly against ice packswrap the pen or vial in a soft cloth or paper towel first

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Routine monitoring of serum calcitonin or using thyroid ultrasound is of uncertain value for early detection of MTC in patients treated with RYBELSUS Important Safety Information for RYBELSUS WARNING: RISK OF THYROID C-CELL TUMORS In rodents, semaglutide causes dose-dependent and treatment-duration-dependent thyroid C-cell tumors at clinically relevant exposures