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A transferase may catalyze an inactivated drug with an endogenous substrate

Biosci Biotechnol Biochem 74(9):19361939 Shuai Y, Zhang T, Mu W, Jiang B (2011) Purification and characterization of gamma-glutamyltranspeptidase from Bacillus subtilis SK11.004

That said: Long-term use should be structured, not random Periodic breaks or reassessment are sensible Quality of formulation matters more than duration Clinically formulated products like Glutone 1000 are designed for sustained use without unnecessary overload

Vaidyanathan A, Sawers L, Gannon A-L et al (2016) ABCB1 (MDR1) induction defines a common resistance mechanism in paclitaxel- and olaparib-resistant ovarian cancer cells