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The international society for cellular therapy position statement

Since mitochondrial defects have been broadly observed in many different diseases in which TDP-43 pathology is commonly detected, and because mitochondria are crucially important for maintaining metabolomic homeostasis, one of the key questions that remains unanswered is: What are the metabolomic changes that occur with respect to TDP-43 pathology? We investigated the metabolomic perturbations that occur in the motor cortex of prp-TDP-43 A315T mice, a mouse model which recapitulates many aspects of TDP-43 pathology observed in ALS and ALS/FTLD patients 19

Aquat Toxicol 19:131161 Winters MJ, Verweij F, Garofalo E, Ceradini S, McKenzie DJ, Williams MA, Taylor EW, Butler PJ, van der Oost R, Chipman JK (2005) Tissue levels and biomarkers of organic contaminants in feral and caged chub ( Leuciscus cephalus ) from rivers in the West Midlands, UK

To this end, we engineered S