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OMIM 602858), the final enzyme in the synthesis of cholesterol, and as a result exhibit abnormally high serum concentrations of 7-dehydrocholesterol and its isomer 8-dehydrocholesterol (67)

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330 Silencing of Notch1 and Jag1 disturbs cell cycle progression to delay liver regeneration

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Krohne TU, Hunt S, Holz FG

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If development started today, oral tirzepatide would likely require 6-11 years to reach FDA approval (typical pharmaceutical development timeline)

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