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24 The inability to manually check these large data sets may pose a challenge in accurately detecting an event as rare as early worsening retinopathy

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MAO-A affects the deamination of serotonin, norepinephrine, epinephrine, and melatonin, whereas MAO-B breaks down phenethylamine and benzylamine

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however, large-scale controlled human efficacy data are not yet available

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This has direct implications for immunotherapy as hypoxia is known to increase PD-L1 expression via HIF-1, enabling immune escape

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