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They concluded from the study that Western style diets especially those with added cholesterol and longer feeding are the closest match across metabolic, histological, and molecular layers and Choline-deficient or genetically driven models may help elucidate specific fibrosis mechanisms but do not recapitulate the full human disease spectrum (302)

Stimuli-responsive nanocarrier systems exploit both internal (pH, redox potential, and enzymatic activity) and external (light, magnetic, or thermal) triggers to achieve on-target drug release while minimizing systemic exposure

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Januzzi, MD, FACC