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Manufacturers must also demonstrate long-term safety, efficacy, and patient adherence to establish strong market positioning and support widespread clinical adoption

Alterations in the normal function of excitatory amino acid carrier 1 affect cysteine transport and GSH synthesis impairing zinc homeostasis (the thiol group of GSH can function as a principal Zn 2+ chelator for the maintenance of Zn 2+ homeostasis in neurons) and oxidative stress, enhancing susceptibility to ischemia-induced neuronal cell death in the hippocampus (162164)

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doi: 10.21608/avmj.2013.191997 160