Pathologically, ALS is characterized by motor neuron degeneration and a constellation of co-occurring molecular abnormalities, including excitotoxicity, mitochondrial dysfunction, oxidative stress, necrosis, altered proteostasis, impaired cytoskeletal trafficking, DNA damage, and dysfunctional RNA metabolism
13 In its phase III clinical study, Donanemab reduced amyloid plaque on average by 84% at 18 months, compared to a 1% decrease for patients on placebo
Lactate also ameliorates colitis in animal studies by inducing the expression of Cdc42 and Pak1, two factors associated with healthy intestinal epithelial cell migration
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