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Some effects have reasonable clinical evidence

Metabolism & aging (preclinical): NAD+-dependent sirtuin and PARP activity has been linked to DNA repair and metabolic regulation in animal models [11]

Xin et al., 2005

These deficits, even when localized to higher frequencies, can induce compensatory plasticity within central auditory circuits extending beyond the original site of damage, producing percepts at dissociated frequencies 7,10,11