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discovered that Guhan Yangsheng Jing, a traditional Chinese patent medicine primarily composed of Polygonatum sibiricum , Epimedium , and Lycium barbarum , ameliorates reproductive damage in diabetic male rats by upregulating the Nrf2/HO-1 pathway to alleviate oxidative stress and ferroptosis [179]

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Most herbal alternatives, including ingredients like chromium picolinate, garcinia cambogia, and conjugated linoleic acid, show modest effects in small studies but lack the sustained appetite suppression and metabolic changes documented in semaglutide trials