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For example, a much smaller patient will need a lower dose, whereas someone with greater body mass or a resistance to the medication will likely need a higher one

Impaired mitochondrial function exacerbates hyperthyroidism associated with ocular manifestations in Graves disease patients ( Oxidative stress damage: During oxidative stress, mitochondria generate excessive free radicals and oxidants, disrupting cellular redox balance of cells

The criteria comprise three features, including oligo or amenorrhea, clinical and biochemical signs of hyperandrogenism, and evidence of polycystic ovaries on ultrasound findings

this is not fat gain, and it stabilizes within a few weeks