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In some cases, GLP-1 medications may not be a good fit

The impact of a ketogenic diet on weight loss, metabolism, body composition and quality of life

HGF/c-Met signaling is a well-established oncogenic pathway: c-Met is amplified or overexpressed in multiple cancers (gastric, lung, renal, hepatocellular) HGF/c-Met activation promotes tumor cell proliferation, survival, invasion, and metastasis c-Met inhibitors are FDA-approved cancer drugs (cabozantinib, crizotinib, capmatinib) A compound that potentiates HGF/c-Met signaling raises theoretical concerns about promoting tumor growth or transformation with chronic use

Acknowledgments We gratefully acknowledge the authors and participants of all public databases from which we used data