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Introduction Metabolic dysfunction-associated fatty liver disease (MAFLD), formerly named as non-alcoholic fatty liver disease (NAFLD), is characterized as excessive lipid accumulation within hepatocytes with overweight/obesity, presence of type 2 diabetes mellitus, or evidence of metabolic dysregulation (Eslam et al., 2020)

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In db/db mice and HK-2 cells cultured with high glucose, calycosin inhibited high glucose-induced ferroptosis by affecting GPX4 and NCOA4 levels[164]

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