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Research ArticleEndocrinologyMetabolism Open Access | 10.1172/jci.insight.141851 1 Department of Biomedical Sciences and 2 Baker Institute for Animal Health, Cornell University College of Veterinary Medicine, Ithaca, New York, USA

These approvals are grounded in pediatric and adult trials ( Notwithstanding the rapid evolution of pharmacotherapeutic options, for pediatric and adolescent patients with obesity, standard care (healthy diet, exercise, and behavior counseling)defined as the integration of healthy dietary adjustments, regular physical activity, and behavioral counselingremains the first-line treatment

Randomization and administration of investigational drug Participants ( n = 39, Intention to Treat (ITT) population) with severe or moderate IPTB risk were randomized to receive either a high-dose NAC regimen or placebo per os , preceded by an initial intravenous ( iv )-infusion in the subgroup of severe IPTB (Fig

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