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In elderly individuals, circadian rhythms as well as sleep-wake regulation are weakened, leading to phase advances, decreased ability to adjust to phase shifts, and reduced amplitude of circadian rhythms (Musiek and Holtzman, 2016), neuronal loss, and imbalances in neurohormonal and neurotransmitter systems arising from age-mediated changes in the central nervous system (Zhong et al., 2019)

73 Contributions of other HSPs to metabolic disease pathogenesis Beyond HSP72, several other HSP family members contribute to metabolic disease development in tissue-specific and context-dependent manners

Keep the solution refrigerated and protected from light

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