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How peptide immunotherapy achieves tolerance The mechanisms include induction of specific T-cell anergy (functional inactivation of allergen-reactive T-cells), differentiation of naive T-cells into regulatory T-cells, immune deviation (shifting the Th2/Th1 ratio toward Th1), and allergen-specific Th2 cell deletion

The semi-rigid vial is fabricated from a specially formulated polyolefin

Start: Begin at 2,667 mcg total (~10 units) once daily to gauge tolerability

The problem is extended room-temperature storage, repeated warming, leaving the vial on a bench, or shipping and storing reconstituted solution outside a controlled cold chain