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Improvements have been observed at the histological level with vitamin E in patients without diabetes, but there is no evidence proving its benefit in patients with diabetes

For instance, Chinese formula Xiaoyaosan alleviates depression-like behaviors by modulating PEBP1-GPX4-mediated ferroptosis in the hippocampus of CUMS mice, implying that ferroptosis could become a novel target for development and research of antidepressant drugs