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364 Sirtuins and PARPs control the genome stability and gene transcription by regulating the histone modification, DNA repair, as well as the recruitment and activation of transcription factors

Interventions such as the antioxidant NAC or the inhibition of MAPK8/JNK activity have been demonstrated to mitigate ROS-induced parthanatos in glioma cells [156], suggesting that MAPK8 activation contributes to parthanatos by enhancing intracellular ROS levels

Differential effects of sulforaphane on histone deacetylases, cell cycle arrest and apoptosis in normal prostate cells versus hyperplastic and cancerous prostate cells