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Evidence includes: Stimulation of endothelial and keratinocyte migration Enhanced blood vessel density in wound healing models Promotion of stem cell differentiation toward repair cell lineages Low molecular weight enabling tissue penetration over long distances Unlike growth factors that bind to extracellular matrix, TB-500s mobility allows systemic distribution to multiple injury sites

For the general patient population, this has no clinical relevance

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Yes, but you may need to reconstitute at a higher concentration (15 mg/mL or 20 mg/mL) to keep the injection volume within a single syringe draw