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Common symptoms can include: Extreme fatigue Lethargy Loss of appetite headaches Feeling faint or dizzy Breathlessness Headaches Heart palpitations Tinnitus Additional symptoms of B12 deficiency can include psychological problems such as low mood, irritability, depression, cognitive changes, or blurred memory

Whether they ever will depends less on the receptor, whose biology is no longer in serious doubt, than on two engineering problems that the recent failures have brought into focus: getting the compound to the right neurons, and getting the right patients into the trial

Arabidopsis Book 9 , e0142 (2011)