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Elevated cardiomyocyte-localized VCPIP1 was detected in diabetic hearts, and cardiomyocyte-specific VCPIP1 knockout markedly rescued cardiac damage in type 1 and type 2 diabetic mouse models

The reasonable reading is that cagrilintides gastrointestinal effects are mechanism-based and generally manageable with titration in the studied populations, but that manageable in trials is not the same as fully characterized for long-term real-world use, and the delayed-emptying mechanism itself carries context-specific cautions that should not be waved away

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Hertz, A