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15,16 On the other hand, TRX reductase (TRXR) utilizes NADPH as an electron donor to maintain the reduced form of TRX, which contributes to scavenge H 2 O 2 and reduce ribonucleotide reductase (RNR) for DNA synthesis

Understanding metabolic dysfunctions in ASD and identification of the specific markers, e.g., glutathione, vitamin E, tetrahydrobiopterin, and antioxidative enzymes such as glutathione peroxidase, paraoxonase, and superoxide dismutase, may direct ASD treatment toward specific metabolic disturbances [23,28]