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Transcription factor activity changes: GHK-Cu modulates activity of key transcription factors including NF-B (inflammation master regulator), AP-1 (stress response), Nrf2 (antioxidant response element activator), p53 (cell cycle and apoptosis regulator)

It is also not recommended for patients with existing gastrointestinal disease to avoid potential side effects or exacerbating the condition

( a ) Schematic and representative images illustrating generation of 5FU resistant AKP organoids by continuous culture in increasing concentrations of drug, images at 4x magnification with mean organoid diameter denoted

The average window period is 26.8 days for these assays79