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| Side effects and tolerability | Practical differences | Cost and access in the UK | Switching between medications | Who might prefer each option

Mounjaro starts at 2.5 mg weekly for four weeks, then increases to 5 mg

According to the pricing structure of the pan-Canadian Pharmaceutical Alliance, the first generic medication could cost 75 to 85 per cent of the brand name

MASLD and metabolic dysfunctionassociated steatohepatitis (MASH), the histologic phenotype of MASLD characterised by liver injury and inflammation in addition to steatosis, is a major public health issue as it increases the risk of liverrelated complications, such as cirrhosis and hepatocellular carcinoma, while also increasing the rates of fatal and nonfatal cardiovascular events, chronic kidney disease, T2D, extrahepatic cancers [1] and severe bacterial and nonbacterial infections [2]