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5 GLP-1 receptor agonists: a multi-functional therapeutic targeting metabolic dysfunction Glucagon-like peptide-1 (GLP-1), a multifaceted hormone expressed primarily in the intestines and pancreas, mediates physiological and behavioral properties through its receptor, GLP-1 receptors (GLP-1R)

Thus, for viral etiologies, the virus acts as the initial trigger, but the resulting metabolic dysregulation and chronic inflammatory state which overlaps significantly with the pathophysiology of MASLD are focused on and ultimately destroy the livers tissue architecture, creating the sustained carcinogenic environment (Wang and Zhang, 2023

Gordan JD, Thompson CB, Simon MC

They slow gastric emptying, increase insulin release, and suppress appetite at the brain level