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The most common side effects of RYBELSUS may include: The most common side effects of RYBELSUS may include: Nausea Vomiting Diarrhea Stomach (abdominal) pain Decreased appetite Constipation Nausea Diarrhea Vomiting Stomach (abdominal) pain Decreased appetite Constipation Nausea Vomiting Diarrhea Stomach (abdominal) pain Decreased appetite Constipation Nausea Diarrhea Vomiting Stomach (abdominal) pain Decreased appetite Constipation Nausea Diarrhea Vomiting Stomach (abdominal) pain Decreased appetite Constipation Nausea, vomiting, and diarrhea are most common when first starting RYBELSUS and when your dose increases