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Unlike many neuropeptides confined to a single physiological system, DSIP exhibits a broad distribution across both neural and peripheral tissues, suggesting involvement in multiple regulatory pathways simultaneously

The metabolite profile produces free proline, which through proline oxidase generates superoxide, which can react with NO to form peroxynitrite

Posted July 21, 2026 Reviewed by Abigail Fagan Key points Scientific breakthroughs often begin with unexpected observations made while caring for patients

Beyond lipodystrophy: metabolic syndrome and cognition Tesamorelin's clinical profile has attracted interest well beyond its approved HIV-lipodystrophy indication