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In our previous study, we observed a significant increase in GRP78 immunofluorescence labeling in 12Z cells following NAC treatment 20 , suggesting an association between NAC and organelle stress responses

It upregulates genes involved in collagen synthesis (COL1A1, COL3A1, COL5A1), extracellular matrix remodeling (decorin, fibromodulin), and antioxidant defense (superoxide dismutase, glutathione peroxidase) while simultaneously suppressing genes associated with inflammation (IL-6, TNF-alpha), fibrinogen production, and tissue destruction (several MMPs)

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Altered thermal responsiveness during regeneration of corneal cold fibers