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PubMed Cardiac Research MOTS-c regulates cellular metabolism through AMPK-dependent pathways, enhancing glucose utilization and stress responses

Gain-of-function mutations in the STING-encoding gene TMEM173 maintains STING in an overactivated state which leads to a persistent IFN signal, and drives a systemic and debilitating inflammatory condition known as STING-associated vasculopathy with onset in infancy (SAVI) (192)

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Supplementing with SAM-e: S-Adenosylmethionine, or SAM-e, is a compound formed by the amino acid methionine and found naturally within the body