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Studies showing the correlation between PCOS and reduced quality of life [15, 16] with the increase in anxiety and depression [17]

Across microneedle technologies, coated microneedles lead on rapid release, dissolving microneedles lead on safety and consumer acceptance, hydrogel microneedles lead on controlled release, and hollow microneedles target specialty clinical settings

In addition to upregulating anti-apoptotic pathways, they evade immune surveillance by modulating immune checkpoints such as GD3 ganglioside 9 and secrete a pro-inflammatory mixture of cytokines, chemokines, and proteases collectively termed the senescence-associated secretory phenotype (SASP) 10,11