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To evaluate the effects of compound on GPX4 activity, compound was first pre-incubated with purified GPX4 in the assay buffer [Tris-HCl (100 mM, pH 7.4), EDTA (5 mM), Triton X-100 (0.1% v/v), NADPH (0.2 mM), glutathione (3 mM), and glutathione reductase (1 unit)] for 5 min at 37C

Proteomic identification of nitrated brain proteins in traumatic brain-injured rats treated postinjury with -glutamylcysteine ethyl ester: insights into the role of elevation of glutathione as a potential therapeutic strategy for traumatic brain injury

Patients in the later period compared with the earlier period had more severe kidney dysfunction (stage 3: 52.1% vs

Unlike obesity, which faces stigma and limited payer support, diabetes is widely recognized as a chronic condition requiring pharmaceutical intervention