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Research shows that CML cells with the BCR-ABL-T315I mutation treated with AKI603 display features typical of senescent cells, such as increased SA--Gal activity, altered morphology, elevated levels of p53, p21, p27, and p16, as well as SASP secretion [79]

10.1016/S2213-2600(19)30374-1 124 MaJ