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It belongs to a class of medications called GLP-1 receptor agonists, which work by stimulating the release of insulin and reducing the production of glucose in the liver

Absolute contraindications Tirzepatide should not be used by anyone with a personal or family history of medullary thyroid carcinoma (MTC) or multiple endocrine neoplasia syndrome type 2 (MEN 2)

Comprehensive programs incorporating: Nutritional counseling emphasizing gradual caloric reduction (500750 kcal/day deficit) Regular physical activity (150 minutes weekly moderate-intensity exercise) Behavioral therapy and support groups Slower weight loss targets (0.51 kg or 12 pounds weekly) This approach minimizes gallstone formation risk through gradual weight reduction while still achieving meaningful health benefits

When combined, these effects may be additive, potentially affecting medication adherence and quality of life