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Possible mechanisms behind the semaglutide-NAION connection include: Rapid weight loss leading to changes in intracranial pressure Alterations in blood flow to the optic nerve Metabolic changes affecting optic nerve function Its important to note that current research has limitations

On the basis of cardiovascular outcomes trials (CVOTs) demonstrating reduced risks of major cardiovascular events (MACE), both GPL-1RAs and SGLT-2is are recommended for T2D patients with high cardiovascular risk [13]

Research in behavioral medicine shows that patients who work with a dietitian or health coach during discontinuation maintain 6075% of their weight loss two years later, compared to 3545% without structured support

4 SURMOUNT-3 study design